Azadeh karami biography
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Azadeh Karami
Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway
by Taher Darreh-shori and Azadeh Karami
PLoS One, 2013
Acetylcholine (ACh), the classical neurotransmitter, also affects a variety of nonexcitable cells...
more Acetylcholine (ACh), the classical neurotransmitter, also affects a variety of nonexcitable cells, such as endothelia, microglia, astrocytes and lymphocytes in both the nervous system and secondary lymphoid organs.
Azadeh karami biography
Most of these cells are very distant from cholinergic synapses. The action of ACh on these distant cells is unlikely to occur through diffusion, given that ACh is very short-lived in the presence of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), two extremely efficient ACh-degrading enzymes abundantly present in extracellular fluids.
In this study, we show compelling evidence for presence of a high concentration